In this bioavailability trial should be shown that the one of the main active constituent in alcoholic echinacea extracts, the alkylamide dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamide (short: tetraen) is bioavailable in children of different age groups after intake of 5 Echinaforce junior tablets.
In this bioavailability trial should be shown that the one of the main active constituent in alcoholic echinacea extracts, the alkylamide dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamide (short: tetraen) is bioavailable in children of different age groups after intake of 5 Echinaforce junior tablets. Six capillary blood draws are taken at the following time points: Start (0), after 15, 30, 60, 90, 270 minutes and thereafter the bioavailability is measured and calculated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Echinacea Purpurea Extract Pill, sweetened and with orange flavour
University Children's Hospital (UZH-UCH), Infectiology, University of Zurich
Zurich, Switzerland
Peak Plasma Concentration (Cmax)
Peak concentration of tetraen
Time frame: 270 minutes measurement
Area under the plasma concentration versus time curve (AUC)
Area of tetraen in plasma versus time curve
Time frame: 270 minutes measurement
Timepoint when Cmax is reached (tmax)
timepoint when maximum tetraen concentration is reached
Time frame: 270 minutes measurement
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