Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Inclusion Criteria: 1. Adult greater than 18 years old, male or female. 2. Patient must be able to understand and communicate with the investigator and comply with the requirements of the study. 3. Typical presentation of NBCCS in the opinion of the investigator 4. At least one of the major clinical criteria of NBCCS. 5. Multiple BCCs during the screening period Exclusion Criteria: 1. Any concomitant dermatological disease that could confound the evaluations, based on the discretion of the investigator. 2. Prior exposure to LDE225. 3. Use of systemic treatment for BCC in the 4 weeks prior to Baseline. 4. Use of topical treatment or photodynamic therapy (PDT) in the 12 weeks prior to Baseline. 5. Use of other investigational drugs at Baseline, or within 30 days or 5 half-lives prior to Baseline, whichever is longer. 6. Clinically significant medical condition, as per judgment of the investigator. 7. History of hypersensitivity to any of the ingredient of the study drug. 8. Pregnant or nursing (lactating) women 9. Women of child-bearing potential and fertile males, UNLESS they are using two birth control methods Other protocol-defined inclusion/exclusion criteria may apply