Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation

King Chulalongkorn Memorial Hospital180 enrolled

Overview

Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

180

Conditions

Kidney Function Kidney Transplant; Complications Delayed Graft Function

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Deceased donor kidney transplantation at KCMH * informed consent is accepted Exclusion Criteria: * Known allergy to furosemide * Surgical complication of allograft * Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)

Outcomes

Primary Outcomes

Urine output

Urine output per hour (milliliters/hour) after furosemide injection

Time frame: 6 hours

Secondary Outcomes

Delayed graft function

Delayed graft function is defined by the necessity of dialysis within the first week after kidney transplantation. (yes/no)

Time frame: 7 days

Creatinine reduction ratio

Ratio of serum creatinine at postoperative day 7 and 14 to day-zero creatinine

Time frame: At postoperative day 0,7 and 14