Role of SWE-change After TIPS in the Prediction of Prognosis After TIPS

Jonel Trebicka83 enrolled

Overview

The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).

We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Portal Hypertension Liver Cirrhoses

Interventions

Stiffness measurementDIAGNOSTIC_TEST

Transient Elastopgraphy (TE) or Shear-Wave-Elastography

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * TIPS insertion and had reliable SWE or TE measurement Exclusion Criteria: * contraindication for TIPS * no reliable SWE or TE measurement

Outcomes

Primary Outcomes

Survival

Time frame: 3 months

Secondary Outcomes

Acute-on-chronic Lvier failure

Time frame: 3 months

Data from ClinicalTrials.gov

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