Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome

Seoul National University Hospital108 enrolled

Overview

In the present study, we evaluated whether RIPC with RIPostC reduce the major neurocomplication in patients undergoing STA-MCA anastomosis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

108

Conditions

Moyamoya Disease Remote Ischemic Preconditioning

Interventions

RIPC with RIPostCPROCEDURE

The sphygmomanometer is closed to the lower limb and the cuff is inflated and the pressure is increased by 30 mmHg higher than the systolic blood pressure of each patient for 5 minutes. The loss of the distal pulse is confirmed by Doppler in the dorsalis pedis pulse. If there is a pulse, increase the pressure until it disappears. After 5 minutes of ischemia time, the cuff is deflated to confirm that the pulse has returned and has a reperfusion time of 5 minutes. A total of 4 cycles of 5 cycles of ischemic time and 5 minutes of reperfusion time are performed. (Estimated total 40 minutes) When the skull is started to close, RIpc with RIPostC group performs RpostC and the method is the same as the above RIPC method. (Estimated total 40 minutes)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. American Society of Anesthesiologists 2. Adults 18 to 65 years of age 3. In patients with planned MCA-STA anastomosis under general anesthesia 4. Patients who pre-agreed to the study Exclusion Criteria: 1. If there is a history of peripheral vascular arterial or venous disease 2. If there is a previous history of peripheral nerve disease 3. Other brain or cerebrovascular disease 4. In case of serious cardiovascular disease, pulmonary disease, kidney disease 5. Patients who do not agree with the test

Locations (1)

Seoul National Univ. Bundang Hospita

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

Number of major adverse event

hyperperfusion syndrome, hypoperfusion, EDH, SAH, acute infarction

Time frame: postoperative one month

Data from ClinicalTrials.gov

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