Rudolph: Nasal Microbiota With Red and Sore Nose

Kimberly-Clark Corporation10 enrolled

Overview

This pilot study will utilize the experimental rhinovirus infection model to study changes in skin microbiota in relation to skin erythema and soreness.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Dermatitis

Interventions

Rhinovirus ChallengeOTHER

Challenge with HRV-16 virus

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * self reported proneness to developing symptoms of nose redness and/or soreness * sero-negative to HRV-16 at screening Exclusion Criteria: * confirmed or self-reported allergic rhinitis * history of nasal or otologic surgery * use of anti-inflammatory medication, recent antibiotics or anti-histamines

Locations (1)

Academic Medical Center

Amsterdam, Netherlands

Outcomes

Primary Outcomes

nasal microbiota composition and occurrence of nose redness and soreness during rhinovirus infection

Taxonomic classification of bacterial strains before and after HRV-16 virus for subjects with a VAS score rating \>37mm

Time frame: change from baseline compared to day 22

Data from ClinicalTrials.gov

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