The Correlation of PD-L1 Expression in Non-small Lung Cancer Tissue and Peripheral Blood T Cell and Serum.

Xinqiao Hospital of Chongqing80 enrolled

Overview

The detection of tissue PD-L1 immunohistochemistry in Non-small cell lung cancer (NSCLC) has an important role in guiding for the treatment of immune detection point. At the same time,tissue detection is time-consuming and laborious, liquid biopsy can reflect the information of tumor tissue,PD-L1 expression in serum and peripheral blood T cell are expected to be simple, rapid, non-invasive means of detection. The project is planned to explore the correlation of PD-L1 expression in non-small lung cancer tissue and peripheral blood T cell and serum..The investigators have designed to detected the expression levels of PD-L1 protein in cancer tissue and detected the expression levels of PD-L1 in peripheral blood T cell and serum.By using variance analysis of repeated measures design information. Thus exploring the correlation of PD-L1 expression in non-small lung cancer tissue and peripheral blood T cell and serum,guiding clinical practice of immunotherapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

NSCLC

Interventions

Liquid biopsyDIAGNOSTIC_TEST

Liquid biopsy

Medical Language ↔ Plain English

Inclusion Criteria: 1. Pathological histology and/or cytology confirmed non-small lung cancer; 2. Voluntarily enrolled to participate in,better compliance, cooperate with experimental observations, and sign informed consent. Exclusion Criteria: 1. Vital organs (e.g., heart, liver, kidney) have serious dysfunction; 2. Patients with a history of autoimmune disease; 3. Patients with participating in other clinical trials at the same time; 4. Other cases that researchers believe that patients should not participate in the present trial.

Outcomes

Primary Outcomes

The match rate of PD-L1 protein expression in non-small lung cancer tissue and peripheral blood T cell .

consistency

Time frame: up to two years

The match rate of PD-L1 protein expression in non-small lung cancer tissue and serum.