Good quality of postoperative analgesia would lead to attenuate or prevent the adverse effects on the common functions of the immune system. We compared the effect of epidural analgesia versus rectus sheath block on postoperative pain and proinflammatory cytokines following malignant urological surgery.
Study groups: 60 patients were included in the study randomly allocated into two groups of 30 patients. Rectus sheath group (RSB): Each patient received bilateral single shot ultrasound guided rectus sheath block under complete aseptic condition in a dose of 30 ml of bupivacaine 0.25% in each side immediately after induction of general anaesthesia. Control group: the patients did not receive any intervention after anaesthesia induction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
60
Each patient received bilateral single shot ultrasound guided rectus sheath block under complete aseptic condition in a dose of 30 ml of bupivacaine 0.25% in each side immediately after induction of general anaesthesia
Assiut university faculty of medicine
Asyut, Egypt
cumulative opioid consumption
study the effect of RSB on cumulative opioid consumption at 24 hours
Time frame: 24 hours postoperative
Numerical rating scale (NRS)
evaluate postoperative pain intensity by NRS
Time frame: 24 hours postoperative
time to first anlgesic request
the first time receiving IV-PCA bolus injection
Time frame: 24 hours postoperative
serum levels of TNF-α
Proinflamatory cytokines
Time frame: at 24 hours postoperative
Serum level of IL-6
Proinflamatory cytokines
Time frame: at 24 hours postoperative
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