Urine, DNA and Clinical Information Collection From Patients With Alport Nephropathy.

Inclusion Criteria: • Able to communicate well with the investigator, to understand and comply with the requirements of the study and able to provide written informed consent (parent or legal guardian for pediatric and adolescent subjects), which must be obtained before any assessment is performed. Alport Subject-Specific Inclusion Criteria: * Participation in CPLATFRM2201 * Physically able to provide a single first-morning urine sample of at least 30 mL (one ounce). Alport patients who have initiated dialysis therapy since participation in CPLATFRM2201 are exempt from this criterion and may still participate in this study. Healthy Volunteer-Specific Inclusion Criteria: • Male and Female Volunteers (may include healthy siblings of Alport patients) aged 5 to 15 years. Exclusion Criteria: Alport Subject-Specific Exclusion Criteria: • None Healthy Volunteer-Specific Exclusion Criteria: * Use of investigational drugs at the time of enrollment, or within 30 days or 5 halflives of enrollment, whichever is longer; or longer if required by local regulations, and for any other limitation of participation in an investigational trial based on local regulations. * Known history of one of more of (a) hematuria (gross or microscopic), (b)audiological deficits, (c) fixed (non-orthostatic) proteinuria, or (d) reduced renal filtration function with serum creatinine (Cr) above the upper limit of the normal age-specific reference range, on at least 2 prior occasions (serum Cr need not be measured specifically for eligibility). * Any other clinically significant underlying medical conditions as judged by the PI.