Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.

Danish Headache Center12 enrolled

Overview

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide. With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Headache, Migraine

Interventions

Carbon monoxideOTHER

carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass

AIROTHER

Room air will be administered as placebo

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Aged 18-50 * 50-100 kg Exclusion Criteria: * Tension type headache more than once/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Exposure to radiation within the last year * Headache within the last 24 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease * Smoking * Primary relatives with current or previous migraine

Locations (1)

Danish Headache Center

Glostrup Municipality, Denmark

Outcomes

Primary Outcomes

Headache scores, 12 hours

Comparison between carbon monoxide and placebo (atmospheric air)

Time frame: 12 hours

Secondary Outcomes

Facial blood flow

Carbon monoxide induced changes in facial blood flow before and after inhalation.

Time frame: [ Time Frame: 0-180 min ]

Data from ClinicalTrials.gov

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