Dexmedetomidine on Post-operative Blood Pressure in Bain Arteriovenous Malformation Embolization

Nan Jiang30 enrolled

Overview

Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score, Ramsay score, and adverse events were recorded.

Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group according to a random number. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score-15 items, Ramsay score, and adverse events were recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Anesthesia

Interventions

DexmedetomidineDRUG

1.2 μg/kg Dexmedetomidine was administered intravenously constantly after tracheal extubation.

normal salineOTHER

equal volume of normal saline was administered intravenously constantly after tracheal extubation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing brain arteriovenous malformation embolization in the fist affiliated hospital, Sun Yat-sen University, aged 18-65 years, available to chat with,and the tracheal tube was extubated after surgery immediately. Exclusion Criteria: * abuse anesthetic analgesics and sedative drugs, or allergic to Dexmedetomidine or other anesthetics, hypotension or bradycardia before surgery, severe pulmonary disease with saturation of pulse oximetry less than 90% before surgery, or patients refused to attend in this study.

Locations (1)

the First Affiliated Hospital of Sun Yetsen University

Guangzhou, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

urapidil consumption

urapidil consumption was recorded by nurses every hour

Time frame: the end of the 6th hour after tracheal extubation

Secondary Outcomes

urapidil consumption on POD1

urapidil consumption was recorded by nurses every hour

Time frame: the total consumption of urapidil on post-operative day 1.

urapidil consumption on POD2

urapidil consumption was recorded by nurses every hour

Time frame: the total consumption of urapidil on post-operative day 2.

Visual Analogue score

visual analogue score was measured by visual analogue scale

Time frame: the end of the 6th hour after tracheal extubation

Visual Analogue score at 24th hour

visual analogue score was measured by visual analogue scale

Time frame: the end of the 24th hour after tracheal extubation

Visual Analogue score at 48th hour

visual analogue score was measured by visual analogue scale

Time frame: the end of the 48th hour after tracheal extubation

Quality of Recovery Score

Quality of Recovery Score was measured by a 15-item quality of recovery scale

Time frame: the end of the 6th hour after tracheal extubation

Quality of Recovery Score at 24th hour

Quality of Recovery Score was measured by a 15-item quality of recovery scale

Central Contacts

Nan Jiang, PhD

CONTACT

86 20 28823350 NJiang_sysu@126.com

Data from ClinicalTrials.gov

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