Intracardiac Flow Remodeling in Athletes

University Hospital, Caen100 enrolled

Overview

The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician. A better knowledge of the physiology of cardiac adaptation to training will enable physicians to correctly determine whether observed patterns of cardiac remodeling are physiological or pathological. This prospective study proposes to assess in a trained-athlete population the cardiac remodeling in response to intensive exercise training. This study is observational, we do not interfere with athlete's training.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Cardiac Remodeling, Ventricular

Interventions

electrocardiogram and echocardiographyOTHER

We retrieved all electrocardiograms and echocardiography made during the clinical examination of each athlete and each sedentary control. * Standard 12 lead ECG * Trans-thoracic echocardiography examination of cardiac function, morphology and intracardiac flow.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18yrs old * Ability to give written consent for participating in the study Exclusion Criteria: * Age \< 18yrs old * Cardiac diseases, arterial hypertension, cardiac devices, diabetes, renal, liver or pulmonary failure

Locations (1)

CHU de CAEN

Caen, Normandy, France

Outcomes

Primary Outcomes

Evaluation of ventricular response to exercise training by echocardiography.

1. 2D- morphological and functional parameters of both left and right ventricles: * end-diastolic and end-systolic dimensions (cm) * left ventricular mass (g) * ventricular end-diastolic and end-systolic areas (cm²) * ventricular ejection fraction (%) * atrial volumes (ml) * diastolic indices by pulsed wave Doppler and tissue Doppler (cm/s) * myocardial deformation by speckle tracking (%) 2. 3D- morphological and functional parameters of both left and right ventricles: * ventricular full volumes (ml) * ejection fraction (%) 3. Intracardiac flow measurements by color Doppler M-mode: estimation of intra ventricular pressure gradients between the base and the apex (mmHg).

Time frame: Day 1

Secondary Outcomes

Evaluation of ventricular response to exercise training by electrocardiogram

* heart rate (bpm), * ventricular hypertrophy (mV) * atrial remodeling (mV)

Time frame: Day 1

Sport and medical history questionnaire

exercise training program, medical past history, cardiovascular risk factors, treatments, doping.

Time frame: Day 1

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.