Pharmacokinetics of IV Formulation

Inclusion Criteria: 1. Subjects will be males or females of any ethnic origin between 18 and 55 years or age and weighing between 50 and 100kg. 2. Females of child bearing potential must be established on a reliable form of contraception and have a negative pregnancy test at screening and Day -1 3. Subjects must be in good health, as determined by a medical history, physical examination, 12-lead electrocardiogram (ECG) and clinical laboratory evaluations (hepatic transaminases must be within normal limits, congenital non haemolytic hyperbilirubinaemia is acceptable) 4. Subjects will have given their written informed consent to participate in the study and to abide by the study restrictions Exclusion Criteria: 1. Female and male subjects who are not, or whose partners are not willing to use appropriate contraception with two reliable forms of contraception or who are not otherwise unable to conceive children (hysterectomy, oophorectomy, tubal ligation or post menopausal). 2. Subjects who have received any prescribed systemic or topical medication within 14 days of the dose administration unless in the opinion of the Investigator and the Medical Monitor the medication will not interfere with the study procedures or compromise safety 3. Subjects who have used any non-prescribed systemic or topical medication (including herbal remedies) within 7 days of the dose administration (with the exception of vitamin/mineral supplements and paracetamol) unless in the opinion of the Investigator and the Medical Monitor the medication will not interfere with the study procedures or compromise safety