Transdermal Testosterone for Poor Responder Patients Undergoing Controlled Ovarian Stimulation Prior to IVF

Wolfson Medical Center30 enrolled

Overview

This study evaluates the efficacy of pre- IVF treatment with transdermal testosterone to enhance ovarian response in poor responders. a randomized controlled trial with two groups, treatment group with transdermal testosterone before IVF treatment and a control group with no treatment.

One of the major challenges of Assisted reproduction technology is treating women with low ovarian response,those women achieve very poor pregnancy rate with IVF. in recent years there is a focus

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infertility, Female

Interventions

Testosterone gelDRUG

treatment with testosterone gel

Eligibility

Sex: FEMALEMin age: 30 YearsMax age: 42 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * infertility patients undergoing ART regular menses normal function of thyroid, liver and kidney normal BMI (19.3-28.9) without use of any fertility drugs in the previous two months Exclusion Criteria: * patients with recurrent implantations failure (3 cycles and more) previous ovarian surgery uncontrolled medical illness severe endometriosis (stage 3-4) contraindication for testosterone use

Locations (1)

Wolfson MC

Holon, Israel

RECRUITING

Outcomes

Primary Outcomes

number of retrieved oocytes

number of oocytes

Time frame: 2 year

Secondary Outcomes

number of clinical pregnancies

number of pregnancies with fetal cardiac activity

Time frame: 2.5 years

Central Contacts

amir Mr shalev, MD

CONTACT

97235028105 amirshalev75@yahoo.com

ariel Mr weissman, Proffesor

CONTACT

97235028106 ariel.weissman@gmail.com

Data from ClinicalTrials.gov

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