The Search for Viral and Bacterial Etiology of Varicocele

Medical University of Warsaw40 enrolled

Overview

This study is to answer the question is there any relationship between viral ( HSV 1 , HSV 2 , HPV 6/11, CMV, HHV 6 , HHV 8, BKV) or bacterial (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum) infection and occurrence of varicocele in men.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Varicocele Viral Infection Bacterial Infections Sonic Hedgehog Expression VEGF Expression

Interventions

subinguinal microscopic varicocelectomyPROCEDURE

During the procedure approximately 1cm long fragment of varicose vein will be taken for further investigation.

open hernia repairPROCEDURE

During the procedure approximately 1cm long fragment of spermatic cord vein will be taken for further investigation.

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * in experimental arm - varicocele grade II or III and infertility and/or pain Exclusion Criteria: * in control arm: presence of varicocele in ultrasound before surgery

Locations (1)

Chair and Department of Urology Warsaw Medical University

Warsaw, Poland

Outcomes

Primary Outcomes

Level of presence od viral or bacterial infection, level of expression of SHH and VEGF in varicose vein wall. .

Qualitative and quantitive analysis (presence and concentration - µl or U/µl in two different laboratory tests.) to detect genetic material (DNA, mRNA) of bacteria/viruses will be performed. The outcomes from both gropus will be compared.

Time frame: one year after finishing recruitment

Data from ClinicalTrials.gov

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