Immune Modulation From Trichuris Suis

University of Aarhus1 enrolled

Overview

Mucosal immunology during helminth infection

The present study investigates the effects of Trichuris suis on human mucosal and systemic immunity in a single self-infected individual.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Crohn Disease Ulcerative Colitis Intestinal Helminthiasis

Interventions

Trichuris suis eggsBIOLOGICAL

Live eggs from swine whipworm, Trichuris suis

Eligibility

Sex: MALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The included volunteer is a researcher within parasitology with main focus on Trichuris trichiura and Trichiura suis. He planned to infect himself and contacted our department with the purpose of being monitored during this infection for safety (medical supervision) and research reasons. The only clinical criterion for his inclusion in the study was that he was healthy. Exclusion Criteria: \-

Outcomes

Primary Outcomes

Faecal egg excretion

Weekly monitoring of fecal egg counts by microscopy

Time frame: 15 weeks

Secondary Outcomes

Mucosal T cell associated cytokines

Biopsy sampling during established infection

Time frame: 15 weeks

Systemic immune parameters (eosinophilia, Subtypes of circulating T cells)

Blood samples every week

Time frame: 15 weeks

Adverse events

Clinical evaluation every week

Time frame: 15 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.