PD-1 Knockout Engineered T Cells for Advanced Esophageal Cancer

Inclusion Criteria: * Histologically confirmed recurrent or metastatic esophageal cancer * Measurable disease * Progressed after standard treatments * ECOG performance status of 0-2 * Expected life span: \>= 3 months * Toxicities from prior treatment has resolved or ≤ grade 1 * Major organs function normally * Women at pregnant ages should be under contraception * Willing and able to provide informed consent Exclusion Criteria: * Other malignancy within 5 years prior to entry into the study, expect for treated non-melanoma skin cancer and cervical carcinoma in situ * Poor vasculature * Disease to the central nervous system * Blood-borne infectious disease, e.g. hepatitis B * History of mandatory custody because of psychosis or other psychological disease inappropriate for treatment deemed by treating physician * With other immune diseases, or chronic use of immunosuppressants or steroids * Pregnancy (women of childbearing potential:Refusal or inability to use effective means of contraception) * Breastfeeding * Decision of unsuitableness by principal investigator or physician-in-charge