Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries

Ruhr University of Bochum64 enrolled

Overview

The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g. HIV-polyneuropathy and fibromyalgia, this study investigates if these alterations are detectable in unilateral peripheral nerve injuries as well.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Peripheral Nerve Injuries

Interventions

PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold.

Quantitative Sensory Testing (QST)DIAGNOSTIC_TEST

QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain.

Nerve conduction studies (NCS)DIAGNOSTIC_TEST

NCS were performed with patients only.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Peripheral Nerve Injury Exclusion Criteria: * Polyneuropathy * Contralateral peripheral nerve injury * Severe psychiatric disorders * Disorders affecting central nervous system

Outcomes

Primary Outcomes

N1-latency

N1-latency of pain-related evoked potentials in ms

Time frame: 1 day

Secondary Outcomes

N1P1-amplitude

Amplitude of pain-related evoked potentials in µV

Time frame: 1 day

Data from ClinicalTrials.gov

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