The Nor-Hand study is a hospital-based observational study including 300 patients with evidence of hand OA by ultrasound and/or clinical examination. The baseline examination (2016-17) consists of functional tests and joint assessment of the hands, medical assessment, pain sensitization tests, ultrasound (hands, acromioclavicular joint, hips, knees and feet), computer tomography (CT) and Magnetic Resonance Imaging (MRI) of the dominant hand, conventional radiographs of the hands and feet, fluorescence optical imaging of the hands, collection of blood and urine samples as well as self-reported demographic factors and OA-related questionnaires. Two follow-up examinations are planned after 3 (2019-20) and 8 years (2024-25), respectively. Cross-sectional analyses will be used to investigate agreements and associations between different relevant measures at the baseline examination, whereas the longitudinal data will be used for evaluation of predictors for clinical outcomes and disease progression.
Study Type
OBSERVATIONAL
Enrollment
300
Conventional radiographs (hands/feet), CT of dominant hand, MRI of dominant hand, ultrasound (hands/shoulder/feet/hips/knees), fluorescence optical imaging of hands
Joint assessment of hands and feet, pain sensitization test and functional tests
Self-reported demographic factors, clinical variables and OA history and symptoms
Diakonhjemmet Hospital
Oslo, Norway
Demographic factors
Self-reported relationship status, education, employment, hand tasks in work/previous work, birth place
Time frame: Baseline
Demographic factors
Self-reported relationship status, social network, education, employment
Time frame: 3 year follow-up
Life style factors
Self-reported physical activity, smoking, use of alcohol (AUDIT-C)
Time frame: Baseline
Life style factors
Self-reported physical activity, smoking, use of alcohol (AUDIT-C)
Time frame: 3 year follow-up
Clinical disease variables
Self-reported year diagnosed with OA, number of years with OA symptoms, OA in family, previous injuries of hand/foot, use of medications, previous steroid injections, use of hand orthoses, use of customized tools, previous surgeries, use of alternative therapies, use of supplements, use of nature cures, use of self-help techniques
Time frame: Baseline
Clinical disease variables
Previous injuries of hand/foot, use of medications, previous steroid injections, use of hand orthoses, use of customized tools, previous surgeries, use of alternative therapies, use of supplements, use of nature cures, use of self-help techniques
Time frame: 3 year follow-up
EuroQol 5 dimensions
Self-reported mobility, self-care, usual activity, pain/discomfort, anxiety/depression
Time frame: Baseline
EuroQol 5 dimensions
Self-reported mobility, self-care, usual activity, pain/discomfort, anxiety/depression
Time frame: 3 year follow-up
Sleep disturbances
Self-reported sleep disturbances
Time frame: Baseline
Sleep disturbances
Self-reported sleep disturbances
Time frame: 3 year follow-up
Michigan Hand Outcomes Questionnaire (MHOQ)
Aesthetic damage subscale
Time frame: Baseline
Michigan Hand Outcomes Questionnaire (MHOQ)
All subscales
Time frame: 3 year follow-up
Localization of joint pain (homonculus)
Self-reported pain during the last 24 hours and previous 6 weeks
Time frame: Baseline
Localization of joint pain (homonculus)
Self-reported pain during the last 24 hours and previous 6 weeks
Time frame: 3 year follow-up
Self-reported joint pain, hand pain, feet pain, fatigue, disease activity
Numeric Rating Scale (0-10)
Time frame: Baseline
Self-reported joint pain, hand pain, feet pain, fatigue, disease activity
Numeric Rating Scale (0-10)
Time frame: 3 year follow-up
Australian/Canadian hand index (AUSCAN)
Self-reported hand pain, stiffness and physical function
Time frame: Baseline
Australian/Canadian hand index (AUSCAN)
Self-reported hand pain, stiffness and physical function
Time frame: 3 year follow-up
Western Ontario and McMaster Universities Arthrtis Index (WOMAC)
Self-reported knee/hip pain, stiffness and physical function
Time frame: Baseline
Western Ontario and McMaster Universities Arthrtis Index (WOMAC)
Self-reported knee/hip pain, stiffness and physical function
Time frame: 3 year follow-up
Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP)
Modified version to assess constant and intermittent pain in patients with hand OA (self-reported)
Time frame: Baseline
McGill Questionnaire
Modified version to assess hand OA pain characteristics (self-reported)
Time frame: Baseline
PainDetect
Modified version to assess neuropathic hand pain (self-reported)
Time frame: Baseline
PainDetect
Modified version to assess neuropathic hand pain (self-reported)
Time frame: 3 year follow-up
Brief Approach/Avoidance Coping Questionnaire (BACQ)
Self-reported approach-oriented and avoidance oriented coping
Time frame: Baseline
Pain catastrophizing scale
Self-reported magnification, rumination, helplessness
Time frame: Baseline
Pain catastrophizing scale
Self-reported magnification, rumination, helplessness
Time frame: 3 year follow-up
Self-efficacy scales
Self-reported ability influence pain and symptoms
Time frame: Baseline
Self-efficacy scales
Self-reported ability influence pain and symptoms
Time frame: 3 year follow-up
Foot Function Index
Self-reported pain in feet, disability, activity restrictions
Time frame: Baseline
Foot Function Index
Self-reported pain in feet, disability, activity restrictions
Time frame: 3 year follow-up
Hormonal factors in women
Menopause
Time frame: Baseline
Hormonal factors in women
Menarche, menopause, gynecological operations, hormone treatment, pregnancies, breastfeeding
Time frame: 3 year follow-up
Use of shoewear
The use of shoes with varying type of forefoot and heels
Time frame: 3 year follow-up
Global health assessment
The evaluation of the global health on Visual analogue scale (VAS)
Time frame: 3 year follow-up
Pain Sensitivity Questionnaire
Pain in different daily-life situations, normally leading to no or little pain
Time frame: 3 year follow-up
Fibromyalgia symptoms
ACR criteria for fibromyalgia
Time frame: 3 year follow-up
Short form 12 Energy
One question from Short form 12 about poor energy
Time frame: 3 year follow-up
Brief Illness Perception Questionnaire
Illness perception related to their hand OA disease and symptoms
Time frame: 3 year follow-up
Height
Examination of height in standing position (performed by medical student)
Time frame: Baseline
Height
Examination of height in standing position (performed by medical student)
Time frame: 3 year follow-up
Weight
Examination of weight in light-weighted clothes (performed by medical student)
Time frame: Baseline
Weight
Examination of weight in light-weighted clothes (performed by medical student)
Time frame: 3 year follow-up
Hip/waist circumference
Examination of hip and waist circumference (performed by medical student)
Time frame: Baseline
Hip/waist circumference
Examination of hip and waist circumference (performed by medical student)
Time frame: 3 year follow-up
Blood pressure
Examination of blood pressure after rest (performed by medical student)
Time frame: Baseline
Blood pressure
Examination of blood pressure after rest (performed by medical student)
Time frame: 3 year follow-up
Heart rate
Examination heart rate after rest (performed by medical student)
Time frame: Baseline
Heart rate
Examination heart rate after rest (performed by medical student)
Time frame: 3 year follow-up
Comorbidity questionnaires and medications
Self-reported comorbidities and medications
Time frame: Baseline
Comorbidity questionnaires and medications
Self-reported comorbidities and medications
Time frame: 3 year follow-up
Hair sample
Small hair sample is collected from the back of the patients´ head for quantification of cortisol
Time frame: Baseline
Joint assessment (examination by rheumatologist)
Bony enlargement, tenderness (Doyle index in hand) and soft tissue swelling in hands and feet, and assessment of the ACR criteria of hand, knee and hip
Time frame: Baseline
Joint assessment (examination by rheumatologist)
Bony enlargement, tenderness (Doyle index in hand) and soft tissue swelling in hands and feet, and assessment of the ACR criteria of hand, knee and hip
Time frame: 3 year follow-up
Grip strength
Bilateral measurement of grip strength using Jamar dynamometer
Time frame: Baseline, follow-up
Grip strength
Bilateral measurement of grip strength using Jamar dynamometer
Time frame: 3 year follow-up
Moberg Pick-Up test
Bilateral measurement of fine motor acitivities (time to pick up small elements and put in the box)
Time frame: Baseline
Moberg Pick-Up test
Bilateral measurement of fine motor acitivities (time to pick up small elements and put in the box)
Time frame: 3 year follow-up
Chair Stand test
Number of chair stands during 30 sec
Time frame: 3 year follow-up
40 m walking test
Time in sec for 40 m walking
Time frame: 3 year follow-up
Pain sensitization tests
Temporal summation, pressure pain threshold (painful finger joint, non-painful finger joint, trapezius muscle, left distal radioulnar joint and tibialis anterior muscle), conditioned pain modulation, light touch
Time frame: Baseline
Pain sensitization tests
Temporal summation, pressure pain threshold (painful finger joint, non-painful finger joint, trapezius muscle, left distal radioulnar joint and tibialis anterior muscle), conditioned pain modulation, light touch
Time frame: 3 year follow-up
Ultrasound examination
Osteophytes, grey-scale synovitis and power doppler activity in hands, AC joint, hips, knees and feet
Time frame: Baseline
Ultrasound examination
Osteophytes, grey-scale synovitis and power doppler activity in hands, AC joint, hips, knees and feet
Time frame: 3 year follow-up
Fluorescence Optical Imaging
Examination of altered microcirculation in the hands
Time frame: Baseline
Fluorescence Optical Imaging
Examination of altered microcirculation in the hands
Time frame: 3 year follow-up
Conventional radiographs
Hands (frontal), feet (frontal, oblique and side images)
Time frame: Baseline
Conventional radiographs
Hands (frontal), feet (frontal, oblique and side images)
Time frame: 3 year follow-up
MRI
MRI of dominant hand
Time frame: Baseline
MRI
MRI of dominant hand
Time frame: 3 year follow-up
CT
CT of dominant hand
Time frame: Baseline
Biobank
Collection of whole blood, serum, plasma and urine
Time frame: Baseline
Biobank
Collection of whole blood, serum, plasma and urine
Time frame: 3 year follow-up
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