POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Xuzhou Medical University215 enrolled

Overview

To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Study Type

OBSERVATIONAL

Enrollment

215

Conditions

Postoperative Cognitive Dysfunction

Eligibility

Sex: ALLMin age: 60 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non-cardiac surgery patients; * Age is greater than or equal to 60 years old; * Han Nationality, mother tongue is chinese; * The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; * The Geriatric Depression Scale (GDS) grade 1 or 2; * The important function without serious heart, brain, liver, kidney, lung and other organs; * The ASA class I or II; * The people signed informed consent. Exclusion Criteria: * The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; * Had severe head and face disease, trauma history or history of surgery; * The serious body disease and tobacco, wine and other substance abuse history; * The presence of malignant tumor with shorter survival disease.

Locations (1)

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

Outcomes

Primary Outcomes

the neuropsychological tests

the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement Test,the Finger Tapping Test, the Word Fluency Test and the Building Block Test.

Time frame: 1 day before surgery(baseline)

Mini-Mental score examination [MMSE]

Mini-Mental score examination \[MMSE\] used for screening of dementia

Time frame: 1 day before surgery(baseline)

the neuropsychological tests

the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement,the Test Finger Tapping Test, the Word Fluency Test and the Building Block Test.

Time frame: within the first 7 days (plus or minus 2 days) after surgery

Mini-Mental score examination [MMSE]

Mini-Mental score examination \[MMSE\] used for screening of dementia

Time frame: within the first 7 days (plus or minus 2 days) after surgery

Data from ClinicalTrials.gov

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