Multicentric, placebo-controlled, double-blinded, three-armed, prospective, randomized controlled trial.150 patients diagnosed with atopic dermatitis will be randomized to arm 1 (irradiation for 30min at 415nm wavelength), arm 2 (irradiation for 30min at 450nm wavelength), and arm 3 (irradiation for 30min at low-dose (placebo)). Irradiation will be scheduled 3 times a week for 8 weeks. Patients will be followed up for four weeks after the last irradiation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
87
Full body blue light irradiation (phototherapy) of atopic dermatitis patients.
University Hospital Goettingen
Göttingen, Germany
University Hospital Marburg
Marburg, Germany
University Hospital Geneva
Geneva, Switzerland
Change in Eczema Area Severity Index (EASI) at end of treatment
Change in EASI from baseline to week 8
Time frame: week 8
Change in Score of Atopic Dermatitis (SCORAD) at end of treatment
Change in SCORAD from baseline to week 8
Time frame: week 8
Change in Patient Oriented Score of Atopic Dermatitis (PO-SCORAD) at end of treatment
Change in PO-SCORAD from baseline to week 8
Time frame: week 8
Change in Investigator Global assessment (IGA)at end of treatment
Change in IGA from baseline to week 8
Time frame: week 8
Change in itch Visual Analogue Scale (VAS) at end of treatment
Change in itch VAS from baseline to week 8
Time frame: week 8
EASI 50%
Proportion of patients achieving 50% reduction from baseline EASI score at end of treatment
Time frame: week 8
Change in Dermatology Life Quality Index (DLQI) at end of treatment
Change in DLQI from baseline to week 8
Time frame: week 8
Change in EASI at follow-up
Change in EASI from end of treatment to week 12
Time frame: week 12
Time until treatment response
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time until Treatment Response is seen
Time frame: week 0-8