Neuroimaging Studies of Smoking and Treatment

University of Kansas Medical Center92 enrolled

Overview

The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Smoking Cessation

Interventions

Cognitive behavioral therapyBEHAVIORAL

Therapy focused on explaining the physiological and psychological effects of nicotine. Training is focused on adherence to smoking instructions, physiological and psychological effects of nicotine, reviewing reasons for quitting, and coping with smoking urges. Smokers will be asked to begin smoking on a set schedule leading up to their quit day.

Health educationBEHAVIORAL

Therapy that provides health education on the importance of healthy eating. Participants will be instructed to smoke as usual.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * smoke \> 10 cigarettes per day * vision is normal or corrected-to-normal Exclusion Criteria: * serious medical illness unsuitable for the MR scanner based on best clinical judgment * any neurologic or psychiatric disorder * diabetes * known heart disease * high blood pressure * currently taking psychotropic or cardiovascular medication * history of alcohol or other substance dependence or current abuse * risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc) * pregnancy

Locations (1)

Hoglund Brain Imaging Center, University of Kansas Medical Center

Kansas City, Kansas, United States

Outcomes

Primary Outcomes

Change in activation in reward processing regions of the brain

Time frame: Change from Baseline to Week 4

Secondary Outcomes

Change in activation in cognitive control regions of the brain

Time frame: Change from Baseline to Week 4

Change in connectivity between reward and cognitive control regions of the brain

Time frame: Change from Baseline to Week 4

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.