This placebo-controlled RCT tests whether dietary supplementation with curcumin maintains or improves cognitive and physical function in older adults who are at high risk of functional decline due existing (mild) functional impairments and elevated biomarkers of inflammation and explore the association between functional changes and changes in biological indicators of active inflammation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
17
Participants will be given curcumin (1000 mg/day), and will be instructed to consume two 500 mg capsules prior to breakfast every morning with a glass of water. Participants will be instructed to follow this dosing regimen throughout the entire three-month treatment period. Compliance with the dosing regimen will be monitored both through interview and by counting capsules left at monthly clinic visits.
Participants will be instructed to consume two capsules prior to breakfast every morning with a glass of water. Participants will be instructed to follow this dosing regimen throughout the entire three-month treatment period. Compliance with the dosing regimen will be monitored both through interview and by counting capsules left at monthly clinic visits.
University of Florida
Gainesville, Florida, United States
Curcumin and Physical Function -Walking
To examine the effects of dietary supplementation with curcumin on changes in physical function walking speed- 400meter walk test.
Time frame: Change in walking speed (meters/second) from Baseline and 3 months
Curcumin and Physical Function - Hand Grip
To examine the effects of dietary supplementation with curcumin on changes in physical function grip strength- hand dynamometer
Time frame: Change in grip strength (kilograms) from Baseline and 3 months
Curcumin and Cognitive Function - Attention & Memory
To examine the effects of dietary supplementation with curcumin on cognitive performance mini-mental state examination. 30 points max. The lower, the worse score.
Time frame: Change in attention from Baseline and 3 months
Curcumin and Pain
To examine the effects of dietary supplementation with curcumin on pain symptoms (pain scale 0-10 with 10 being the worst)
Time frame: Baseline and 3 months
Curcumin and Inflammation - Interleukin-6
To examine the effects of dietary supplementation with curcumin on markers of systemic inflammation Interleukin-6 (ng/ml)
Time frame: From Baseline and 3 months
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