Prospective, Multicenter, Observational Study of Apatinib Single or Combined Capecitabine for Treatment of Patients With Metastatic Her-2 Negative Breast Cancer

Inclusion Criteria: * 18 to 70 years old (female) * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Pathologically diagnosed with her-2 negative, ER/PR negative, ER/PR positive after the failure of endocrine treatment, and had not more than three chemotherapy regimens (must include anthracycline-based and yew class), and the final failure of chemotherapy regimens in patients with advanced breast cancer; Note: treatment failure include (1) during or after the completion of six months or less disease progress of neoadjuvant or adjuvant therapy; (2) rescue treatment in progress within 3 months or less * Patients with at least one measurable lesions of the advanced breast cancer， measurable lesions has not received radiotherapy or other treatment, unless progress after treatment (measuring≥10mm on spiral CT scan, satisfying the criteria in RECIST1.1 and WHO); * Major organ function has to meet the following certeria: 1. For results of blood routine test (without blood transfusion within 14 days) 1. HB≥100g/L; 2. ANC≥1.5×109/L; 3. PLT≥75×109/L; 2. For results of blood biochemical test： 1. TBIL\<1.5ULN； 2. ALTand AST\<2.5ULN, but5\<ULN if the transferanse elevation is due to liver metastases； 3. Serum creatinine ≤1.25ULN , or calculated creatinine clearance\>45 ml/min(per the Cockcroft-Gault formula); 6.Participants were willing to join in this study, and written informed consent. Exclusion Criteria: 1. The patients with the failure of capecitabine treatment； 2. The patients with chest wall invasion, or chest wall large canker has a tendency to transfer； 3. Have high blood pressure and antihypertensive drug treatment can not control (systolic blood pressure \> 140 mmHg, diastolic blood pressure \> 90 mmHg), with classⅡand above coronary heart disease, unable to control arrhythmia (including QTc lengthened women \> 470 ms) and classⅢ-Ⅳcardiac insufficiency; or Left ventricular ejection fraction (LVEF) \< 50%； 4. A variety of factors influencing oral drugs (such as unable to swallow, after resection of the gastrointestinal, chronic diarrhea and intestinal obstruction, etc.)； 5. Has a history of bleeding, the clinical significance of bleeding symptoms, patients with definite bleeding tendency, such as gastrointestinal bleeding, bleeding ulcers, baseline period （+ +）and above of defecate occult blood, vasculitis, etc； 6. Received a major surgery within 4 weeks or severe traumatic injury, fractures, or has a poor healing wound； 7. Allergic to apatinib and supplementary material； 8. Patients with active brain metastases; 9. Patients with pregnant or planning a pregnancy; 10. The researchers think inappropriate.