Thirty-eight periodontitis- and diabetes-affected subjects will be randomly allocated to non surgical periodontal treatment with either Full-Mouth Approach (FM-SRP) or Quadrant approach (Q-SRP). Patients will be seen one day and three months (study completion) after treatment. The 24 hours appointment will be occurring after the entire completion of the FM-SRP or the first quadrant of the Q-SRP. In the latter group other sessions of treatment will be performed within the following 3 weeks. At baseline, 24 hours and three months, anthropometric, inflammatory and endothelial parameters will be collected. Periodontal parameters will be checked at baseline and at three months. Main outcome of the study is the level of C-reactive protein 24 hours after treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
38
Non surgical periodontal treatment performed in all dentition within 1-2 appointments in a 24 hour time frame.
Non surgical periodontal treatment performed in 4 sessions comprising of a quadrant (1/4) of the dentition each. Performed in 3 weeks time frame.
University Hospital of Pisa
Pisa, Italy
Levels C-Reactive Protein
Changes in C reactive protein (CRP). Unit of measure: mg/L
Time frame: Baseline, 24 hours and 3 months after treatment
Full Mouth Plaque Score (FMPS)
Changes in FMPS. Unit of Measure: %
Time frame: Baseline and 3 months after treatment
Full Mouth Bleeding Score (FMBS)
Changes in FMBS. Unit of Measure: %
Time frame: Baseline and 3 months after treatment
Pocket probing depth (PPD)
Changes in PPD. Unit of measure: mm
Time frame: Baseline and 3 months after treatment
Clinical attachment level (CAL)
Changes in CAL. Unit of measure: mm
Time frame: Baseline and 3 months after treatment
Recession of the gingival margin (REC)
Changes in REC. Unit of measure: mm
Time frame: Baseline and 3 months after treatment
Triglycerides
Changes in triglycerides. Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
Low-density lipoprotein (LDL)
Changes in LDL. Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
High-density lipoprotein (HDL)
Changes in HDL. Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
Cholesterol
Changes in total cholesterol, Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
Glycemia
Changes in blood glucose level. Unit of measure: mg/dl
Time frame: Baseline, 24 hours and 3 months after treatment
Glycated Haemoglobin
Changes in Glycated haemoglobin. Unit of measure: mmol/mol
Time frame: Baseline, 24 hours and 3 months after treatment
Insulin
Changes in Insulin level
Time frame: Baseline, 24 hours and 3 months after treatment
Systolic Blood Pressure (SBP)
Changes in SBP Unit of measure: mmHg
Time frame: Baseline, 24 hours and 3 months after treatment
Diastolic Blood Pressure (DBP)
Changes in DBP. Unit of measure: mmHg
Time frame: Baseline, 24 hours and 3 months after treatment
Endothelial Function
Measures of endothelial function taken through Flow-Mediated dilation. Unit of Measure: %
Time frame: Baseline, 24 hours and 3 months after treatment
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