Pharmacokinetics and Safety of Fevipiprant in Patients With Renal Impairment Compared to Matched Healthy Subjects

Inclusion Criteria: * Healthy subjects must satisfy the criteria for normal renal function as evidenced by normal Glomerular Filtration Rate (GFR): eGFR ≥ 90 mL/min/1.73m2; each healthy subject must match in age (+/- 10years), gender, smoking status, and weight (+/- 15%), a patient from the renail impaired patient groups: * A body mass index (BMI) within the range of 18 - 36 kg/m2 * ESRD patients on hemodialysis: an glomerulo filtration rat GFR of \< 15 mL/min/1.73 m2 * patients with severe renal impairment: GFR of\< 30 mL/min/1.73m2 (without need of hemodialysis); * patients with moderate renal impairment: 30 mL/min/1.73m2 ≤ eGFR \< 60 mL/min/1.73m2; * patients with mild impairment: 60 mL/min/1.73m2 ≤ eGFR \< 90 mL/min/1.73m2 Exclusion Criteria: * Pregnant or nursing (lactating) women * History or evidence of any inherited bilirubin disease or disorder * subjects participating in another study * malignancies in the past * Hemoglobin levels below 10 g/dL at screening * HIV positiv * Heavy smokers (≥20 cigarettes per day) * Liver disease, as indicated by ALT, γ-GT, AST and alkaline phosphatase which should not exceed twice the upper limit of normal and should be stable (e.g. increased liver values known from previous patient records). Serum bilirubin \> 27 μmol/L (1.6 mg/dL) * Clinically significant ECG changes and/or arrhythmias * Chronic infection with Hepatitis B (HBV) or Hepatitis C (HCV)