Expression of Molecular Markers in Circulating Tumor Cells of Metastatic Castration-Resistant Prostate Cancer

Inclusion Criteria: 1. Male patients 2. 18 yrs and older, and 80 yrs and younger 3. Histologically or cytologically proven prostate adenocarcinoma; 4. Imaging examinations including Emission Computed Tomography (ECT), Positron Emission Tomography (PET) and so on revealed a high-volume disease of patients(A high-volume of disease was defined by the presence of visceral metastases or four or more bone lesions with at least one beyond the vertebral bodies and pelvis) 5. Have been received hormonal therapy and progressed into castration-resistant stage 6. Not yet receiving chemotherapy 7. Patients are willing to participate and can be followed up regularly Exclusion Criteria: 1. Received the treatment of abiraterone acetate previously 2. Patients received chemotherapy previously 3. Combined with other malignant tumor history (in addition to the skin basal cell carcinoma or other tumors that have been cured more than five years).