MicroRNAs in Acute Kidney Injury

Heinrich-Heine University, Duesseldorf150 enrolled

Overview

Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?

In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Kidney Injury in Cardiac Surgery - Expression of microRNAs

Interventions

observation of microRNA expressionOTHER

no intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * cardiac surgery Exclusion Criteria: * preexisting chronic kidney injury * inclusion in another study * pregnancy * Kidney transplantation in history * GFR \< 30 ml/min (glomerular filtration rate) * ECLS therapy (extracorporal life support)

Locations (1)

Klinik für Anästhesiologie

Düsseldorf, Germany

Outcomes

Primary Outcomes

acute kidney injury

AKI Stadium II or III following cardiac surgery.

Time frame: 1 year

Data from ClinicalTrials.gov

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