The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
Study Objectives: We aim to: 1. Quantitate CNS autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries. We also aim to characterize the temporal course of this response. 2. Characterize how CNS autoantibody levels correlate with specific injury patterns as well as radiographic and clinical measures of injury severity. 3. Determine how intercurrent infection and a history of prior CNS insult affects the temporal course and magnitude of autoantibody production.
Study Type
OBSERVATIONAL
Enrollment
63
University of Utah Hospital
Salt Lake City, Utah, United States
Quantitate Autoantibodies
Quantitate CNS autoantibody development and temporal course in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
Time frame: 5 years
Autoantibody Correlation
Characterize how CNS autoantibody levels correlate with specific injury patterns as well as radiographic and clinical measures of injury severity.
Time frame: 5 years
Autoantibody Production and History
Determine how intercurrent infection and a history of prior CNS insult affects the temporal course and magnitude of autoantibody production.
Time frame: 5 years
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