Intra-articular Injection in the Knee of Adipose Derived Stromal Cells and Platelet Rich Plasma for Osteoarthritis

Inclusion Criteria: * patients age 50 or older who present with symptomatic primary osteoarthritis of the knee * daily pain for the previous 3 months * analgesics usage at least once a week * less than 30 minutes of morning stiffness * WOMAC score of ≤ 75 in the target knee * Brandt Radiographic Grading Scale of Osteoarthritis grade 1 and 2 Exclusion Criteria: * evidence of secondary knee osteoarthritis * severe osteoarthritis (Joint space width - JSW \< 2 mm) * prior intra articular injections within the previous one year prior to inclusion * patients with clinically significant systemic disease