Using Breath Metabolites to Determine Specific Virus Infection in Asthmatic Patients

University of California, Davis19 enrolled

Overview

Respiratory virus infections cause a majority of asthma exacerbations in the fall to spring months. Current diagnostic platforms for respiratory viruses have limitations including cost, availability, and invasiveness. The use of noninvasive breath collection to analyze breath metabolites may be used to differentiate virus-infected asthmatics from other causes of acute asthma exacerbations.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Upper Respiratory Tract Infections, Asthma, Exhaled Breath

Interventions

Exhaled breath condensate collectionDIAGNOSTIC_TEST

Breath from humans is cooled, condensed, and collected

Eligibility

Sex: ALLMin age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Asthma, Age ≥12, Symptoms/signs of an early asthma exacerbation, Ability to provide exhaled breath condensate (EBC) x15 min, Body mass index (BMI) ≥18 Exclusion Criteria: * Chronic lung diseases other than asthma (e.g., chronic obstructive pulmonary disease \[COPD\], lung cancer, fibrotic lung disease, etc.), Smoking in the past 7 days, Eating or non-clear liquids \<4 hrs prior to EBC collection, Pregnancy

Locations (1)

University of California Davis Medical Ceneter

Sacramento, California, United States

Outcomes

Primary Outcomes

Breath metabolite differences between groups

Metabolites from breath will be identified and quantified using gas chromatography-mass spectrometry; these will be compared between groups. Specific breath metabolites include isoprostane, linear and branched alkanes (C6-C9), alcohols, and thiol-containing moieties. However, we will also measure metabolites in an un-targeted manner.

Time frame: 36 months

Data from ClinicalTrials.gov

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