Subgingival Microbiota Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Periodontitis Patients

Peking University12 enrolled

Overview

The investigators planed to observe the microbiome of an aggressive periodontitis patient, during mechanical treatment, surgery(if indicated) and implant placement. The investigators designed to observe the changes after mechanical treatment.Then, the investigators will compare the sub-mucosa microbiome of implant and the subgingival community. The investigators expected a different community after treatment, and there could be similarity between implant and nature teeth.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aggressive Periodontitis, Generalized

Interventions

mechanical treatment(mainly scaling and root planing), periodontal surgery(if indicated), implant placement.PROCEDURE

The investigators shall follow the regular procedure to these patients.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Subjects were between 18-35 years old and diagnosed with generalized aggressive periodontitis (GAgP) according to the 1999 International Classification of Periodontal Diseases (Armitage 1999); 2. At least 20 teeth in the first appointment and at least 3 teeth(other than first molars and central incisors)with a probing depth(PD) ≥ 6mm, clinical attachment level (CAL)≥5mm; 3. The clinical diagnosis was confirmed by evidence of inter-proximal bone loss on full-mouth periapical radiographs; 4. Family history of aggressive periodontitis. Exclusion Criteria: 1. Uncontrolled systemic conditions including diabetes and hypertension; 2. Pregnant or lactating; 3. Smoking; 4. Received periodontal treatment within the previous 6 months or antibiotic medication during the previous 3 months.

Locations (1)

Peking university hospital of stomatology

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community)

the diversity of subgingival community before and after mechanical treatment

Time frame: Baseline, 6 weeks after mechanical treatment

changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community)

the diversity of submucosa community before and after implatation

Time frame: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years.

changes of prevalence and abundance of OTUs

compute and compare the prevalence and abundance of OTUs

Time frame: Baseline, 6 weeks after mechanical treatment

changes of prevalence and abundance of OTUs

compute and compare the prevalence and abundance of OTUs

Time frame: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years.

Secondary Outcomes

changes of bleeding index

bleeding index after probing

Time frame: Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years.

changes of probing depth

probing depth of indicated sites

Time frame: Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years.

Data from ClinicalTrials.gov

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