In health,adipose tissue stores fat from the diet. If the fat tissue stops storing dietary fat then this increases the chance of it being stored in the liver, which is related to increased risk of heart disease and type 2 diabetes. It has been suggested that having a diet high in sugars or certain fats, may cause the fat tissue and liver to change how they function; we would like to investigate this in detail.
This research aims to investigate how the overconsumption of specific macronutrients may effect adipose tissue and liver metabolism and function. Liver and heart fat content and adipose tissue and liver metabolism fasting and postprandial lipid metabolism will be assessed before and after the specific dietary intervention.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
100
Subjects will be studied before and then after the consumption of a diet where specific nutrients are provided in excess.
Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, United Kingdom
RECRUITINGLiver de novo lipogenesis
Investigators will utilise stable isotope tracer methodology to measure the change in the contribution of newly synthesised fatty acids to very low density lipoprotein triglyceride
Time frame: Within 21 days after starting the intervention diet
Adipose tissue metabolism
Investigators will measure the change in the expression of key lipogenic genes in subcutaneous adipose tissue
Time frame: Within 21 days after starting the intervention diet
Liver fat accumulation
Investigators will measure the change in the amount of fat within the liver using MRI/S
Time frame: Within 21 days after starting the intervention diet
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