Physical Training in Patients With Relapsing Polychondritis

University of Sao Paulo10 enrolled

Overview

Physical training may improve physical capacity and health parameters in various systemic autoimmune diseases. Therefore, the present study will assess the role of an exercise training program in patients with relapsing polychondritis.

Impact of physical training in patients with relapsing polychondritis.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Physical Activity

Interventions

Physical trainingOTHER

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Fullfill the classification criteria of McADAM et al. (1976) * Using prednisone ≤ 0.5 mg/kg/day in the last three months * Sedentary Exclusion Criteria: * Disease relapsing * Overlapping disease * Chronic and/or current infections (viral, bacterial or fungal) * Patients undergoing major surgery within six months before the study * With commitment to ambulation (joint affection in limbs) * Smoking * Diabetes mellitus

Locations (1)

Samuel Katsuyuki Shinjo

São Paulo, Brazil

Outcomes

Primary Outcomes

Cardiopulmonary test

Patients will undertake a maximal graded exercise test on a treadmill, with increments in velocity and grade at every minute until volitional exhaustion. VO2peak will be considered as the average of the final 30 s of the test. Ventilatory threshold (VAT) will be determined when ventilatory equivalent for VO2 (VE/VO2) increased without a concomitant increase in ventilatory equivalent for carbon dioxide (VE/VCO2). Respiratory compensation point (RCP) will be determined when VE/VO2 and VE/VCO2 increased simultaneously.

Time frame: 12 weeks

Secondary Outcomes

Strength muscle tests

The dynamic 1-RM for the leg-press and the bench-press exercises, arm curl (with the dominant arm), and isometric strength (assessed by handgrip, with the dominant arm) will be assessed at baseline and after the intervention.

Time frame: 12 weeks

Healthy Assessment Questionnaire (HAQ)

Especific questionnaire to assess the quality of life. Pontuaction: 0.00-3.00

Time frame: 12 weeks

Functional muscle tests

Muscle function will be evaluated through the TUG and the TST tests

Time frame: 12 weeks

Muscle biopsy

After local anesthesia, a cutaneous incision will be made in lateral thigh face. The biopsy will be done using the Bergstrom needle. Histological (hematoxylin and eosin)/immunohistochemical (CD4, CD8, CD68, CD20, C5b-9, MHCI, MHCII, CD31) analysis will be performed in muscle samples (at baseline and after 12 weeks) in all patients (present study)

Time frame: 12 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.