Kinematics After Total Knee Arthroplasty

Kristin Zhao, PhD

Overview

The purpose of this study is to evaluate and compare implant kinematics of conventional mechanically aligned and anatomically aligned total knee arthroplasties (TKA) at 1 year post-operatively.

Participants will be randomized to receive a primary TKA using either an anatomic alignment or a conventional mechanical alignment technique. Participants will undergo a kinematic analysis of a deep knee bend using single-plane fluoroscopy at 1 year post-operatively. The primary outcome will be based on the 6 degree of freedom kinematics and associated joint component proximity during the knee bend task. Secondary outcomes include the Knee Society Score, the Knee Injury and Osteoarthritis Outcome Score, and the Forgotten Knee Score.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Conditions

Osteoarthritis, Knee

Interventions

DePuy ATTUNE total knee arthroplasty systemDEVICE

A standard midvastus approach will be used for both alignment technique groups. This is a standard approach for exposing the knee joint for TKA.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Males and females * Primary arthroplasty for treatment of osteoarthritis * Age between 40 and 80 years old * Willingness to provide written consent for study participation Exclusion Criteria: * Revision arthroplasty * Pre-operative knee flexion lower than 90 degrees * Varus knee deformity greater than 15 degrees * Pre-operative valgus knee deformity * Presence of infections, highly communicable diseases or metastatic disease * Significant neurological or musculoskeletal disorders or disease that may interfere with normal gait or weight bearing * Congenital, developmental, or other bone disease or previous hip surgery that may, in the surgeon's judgment, interfere with total knee prosthesis survival or success * Presence of previous prosthetic knee or hip replacement device * BMI \> 40 * Pregnant women

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Knee motion, as determined by 6 degree freedom of movement kinematics and associated joint proximity during the knee bend task.

Time frame: 1 year post surgery

Secondary Outcomes

Participants perception of knee function, as determined by the Knee injury Osteoarthritis Outcome Score (KOOS)

Time frame: 1 year post surgery

Participant's awareness of the joint implant, as determined by the Forgotten Joint Score (FJS-12)

Time frame: 1 year post surgery

Knee joint and ambulatory function based on physical exam, as determined by the Knee Society Score (KSS)

Time frame: 1 year post surgery

Data from ClinicalTrials.gov

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