The aim of this study was to conduct a prospective randomized trial to compare TIPS with 8mm expanded polytetrafluoroethylene(ePTFE)-covered stents and endoscopic variceal ligation plus propranolol for the prevention of recurrent esophageal variceal bleeding in patients with Child A cirrhosis
For the prevention of recurrent esophageal variceal bleeding, previous clinical studies and meta-analysis show that patients treated with transjugular intrahepatic portosystemic shunt (TIPS) have lower rebleeding rates compared with endoscopic therapy. However, TIPS is associated with higher rates of portosystemic encephalopathy and does not show survival benefit. TIPS with a small-diameter may achieve sufficient portal decompression and reduce the incidence of hepatic encephalopathy. The aim of this study was to conduct a prospective randomized trial to compare TIPS with 8mm ePTFE-covered stents and endoscopic variceal ligation plus propranolol for the prevention of recurrent esophageal variceal bleeding.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
72
Patients in this group would underwent TIPS placement with 8mm-diameter ePTFE-covered stents.
Patients in this group would underwent sequential endoscopic variceal ligation and propranolol treatment.
Appropriate dose of propranolol was administered to the patients.
West china hospital
Chengdu, China
RECRUITINGVariceal rebleeding rate
Analysis
Time frame: 3 years
Hepatic encephalopathy rate
Analysis
Time frame: 3 years
TIPS dysfunction rate
Analysis
Time frame: 3 years
The incidence of complications
Analysis
Time frame: 3 years
Mortality rate
Analysis
Time frame: 3 years
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