Quality of Life Intervention for Patients Receiving Radiation Therapy for Advanced Cancer Treatment and Their Caregivers

Inclusion Criteria: * 18 years of age. * Ability to attend all treatment sessions and follow-up. * Ability to provide written informed consent. * Ability to participate in all aspects of the study. * Initial diagnosis of cancer must have been 12 months prior to study entry. * Intermediate to poor prognosis, defined as an expected 5-year survival of 0%-50% in the judgment of the physicians entering the patient on the study. * Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0, 1, or 2. * 1 week of planned cancer treatment (radiation or chemotherapy) at Mayo Clinic. * Has a caregiver also willing to participate. * Willingness to get e-mail/text reminder to complete the follow-up survey or complete the follow-up survey with a study coordinator by phone. Exclusion Criteria: * Expected survival of \<6 months. * Active substance abuse (alcohol or drug). * Participation in other psycho-social research trials. * Active untreated thought disorder (bipolar illness, schizophrenia, etc.). * Untreated suicidal intent or plan. * In need of psychiatric hospitalization. * Recurrent disease after disease-free interval of \>6 months. * Previous cancer 5 years (except non-melanoma skin cancer and/or second cancer diagnosed at approximately the same time as this cancer). * Use of Proton Beam Radiation.