EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso

University of Oklahoma58 enrolled

Overview

This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in three Provinces of Burkina Faso. The study design included an 18-months baseline study to measure baseline cumulative incidence of cysticercosis followed by an 18-month post randomization study to measure the effectiveness of the intervention. Sixty villages of three Provinces of Burkina Faso were included. The primary outcome was the change in the baseline to post randomization cumulative incidence in the intervention group compared to the control group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Cysticercosis

Interventions

The educational package was offered to 30 villages post randomization. The field team completed the SARAR PHAST with community members for 2-3 days in each intervention village. The movie was projected every night for 2-3 days in each intervention village.

Eligibility

Sex: ALLMin age: 5 YearsHealthy volunteers:

Medical Language ↔ Plain English

The unit of randomization and analysis of this study is the village. Therefore, the eligibility criteria were determined at the village level. Inclusion Criteria: * Population of at least 1000 at the 2006 census * Present on the map of the "Institut Géographique du Burkina 2000" * Separated from another village by at least 5 kilometers. Exclusion Criteria: * Village located on a National or Provincial road * Village located within 20 km of Koudougou or Ouagadougou * Regional or Provincial Capital * Absence of pigs in the village At the individual level, the following eligibility criteria were used: Inclusion Criteria: * Aged 5 years old or more * Has lived in the village for at least 12 months * Not planning to move in the next three years Exclusion Criteria: * Presence of confirmed epilepsy or progressively worsening severe chronic headaches at baseline.

Outcomes

Primary Outcomes

Human active cysticercosis cumulative incidence

Sero conversion to the AgELISA test to detect antigens of cysticercosis

Time frame: baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization

Secondary Outcomes

Porcine active cysticercosis prevalence

Sero-positivity to the AgELISA test to detect antigens of cysticercosis

Time frame: baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization

Change in knowledge, attitude and practices

Change in answers to the questionnaire through time

Time frame: baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization

Cumulative incidence of epilepsy and progressively worsening severe chronic headaches

development of neurological disorders among those followed up at least twice

Time frame: baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization

Stigmatization of epilepsy

Attitudes and knowledge regarding epilepsy post randomization

Time frame: 18 months follow-up post randomization

EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes