Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil65 enrolled

Overview

The purpose of the study is to measure the negative cognitive consequences of the ventilation under pathological or experimental cortical drive to breath.

Cognitive capacities are measured on healthy subject submitted to inspiratory threshold loading, patients treated by chronic mechanical ventilation due to suffering Ondine syndrome or amyotrophic lateral sclerosis. The spontaneous breathing is compared to NIV breathing or inspiratory threshold loading.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ondine Syndrome Healthy Amyotrophic Lateral Sclerosis

Interventions

Neuropsychological testsOTHER

A battery of tests to evaluate the overall cognitive performance of the subjects (memory, executive, attentional or instrumental functions)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults and non-vulnerable adults * Fluent in French Exclusion Criteria: For patients: * Total ventilatory dependency * Coexistence of an other respiratory disease * Alcohol and /or psychotropic consumption during the last 24 hours * One or more episodes of acute respiratory failure during the past 6 months * Serious cognitive deficiency or presence of fronto temporal dementia * End-stage disease * No affiliation to social security For healthy volunteers: * Existing respiratory disease * Alcohol and /or psychotropes consumption during the last 24 hours * Tobacco smoking more than 2 pack-years * Sleep deprivation * Serious cognitive deficiency * No affiliation to social security

Locations (1)

INSERM-UPC UMR_S 1158, Service de Pneumologie et Réanimation, GH Pitié-Salpêtrière

Paris, France

Outcomes

Primary Outcomes

Score at PASAT (Paced Auditory Serial Addition Test)

Performances will be assessed by counting the number of good and wrong answers, and comparing it in two conditions : spontaneous breathing (SB) versus inspiratory resistive loading for healthy subjects, and SB versus non invasive ventilation for patients.

Time frame: 3 hours

Secondary Outcomes

Oxygen saturation changes

Modifications of oxygen saturation measured using a saturometer placed on the subject's finger.

Time frame: 3 hours

Data from ClinicalTrials.gov

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