Adaptive Radiotherapy for Head and Neck Cancer

Inclusion Criteria: * Participants with pathologically confirmed cancers of paranasal sinuses, oropharynx, oral cavity, nasopharynx, larynx, hypopharynx, and unknown primary and will receive definitive radiation therapy with or without chemotherapy. * Karnofsky performance status \>= 70% * Women of childbearing potential need to have a negative serum pregnancy test at the time of therapy * Participants must have the ability to understand and the willingness to sign a written consent form Exclusion Criteria: * Female participants who are pregnant or breast feeding * Participants who are not able to comply with study and/or follow up procedures * Participants who have received induction chemotherapy before radiation treatment * Participants who had prior head and neck radiation therapy * Participants who are enrolled in a national/international cooperative group trials * Patients with metastatic disease