Use of Pancreatic Enzymes in Short Bowel Syndrome

Inclusion Criteria: * history of a small bowel resection with subsequent dependence on parenteral nutrition for at least three months * age 4 years to 65 years * usual state of health for the past two weeks with no medication changes * able to participate in a study for about four weeks with four study visits * able to take pancreatic enzyme medication orally Exclusion Criteria: * significant disease other than short bowel syndrome affecting the gastrointestinal tract that impacts absorption or digestions * motility disorder * medications that directly alter fat absorption * cholestatic liver disease defined as a serum conjugated bilirubin greater than 1.0 mg/dL, chronic renal failure, gout, or hyperuricemia * history of a pork allergy * women who are pregnant or lactating * history of fibrosing colonopathy Those subjects who are eligible for the malabsorption blood test (MBT) test will be excluded if they have a history of a soy or safflower oil allergy.