Precision Allergy: Separate Allergies to Male and Female Dogs

Copenhagen Studies on Asthma in Childhood22 enrolled

Overview

A new male-specific dog-allergen-component has been found (Can f 5) which indicates possible differences in allergic reactions to male and female dogs. This has not yet been tested in real life. The aim is to test if sensitization only to the male-dog specific allergen-component, Can f 5, results in a positive skin prick test (SPT) to male dog extract and not female dog extract. In addition, the investigators want to investigate if allergic symptoms only occur when exposed to the male dog extract by conjunctival provocation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

QUADRUPLE

Enrollment

Conditions

Allergy; Dander

Interventions

Male dogDIAGNOSTIC_TEST

Male dog extract

Female dogDIAGNOSTIC_TEST

Female dog extract

Eligibility

Sex: ALLMin age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participants in the COPSAC 2000 cohort * Positive component test (\>0.3 ISU) to Can f 1, Can f 2, Can f 3 or Can f 5 Exclusion Criteria: * Uncontrolled asthma * Eye-surgery within the past 6 months * Antihistamine allergy * and others

Locations (1)

Copsac, Dbac

Gentofte Municipality, Copenhagen, Denmark

Outcomes

Primary Outcomes

Male vs. female dog SPT in Can f 5 mono sensitized patients

In the patients that have a positive SPT (\> 2mm) to dog and are monosensitized to the Can f 5 component, the investigatiors want to compare the reaction to SPT (pos/neg) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures.

Time frame: 6 months

Secondary Outcomes

Male vs. female dog conjunctival provocation in Can f 5 mono sensitized patients

In the patients that have a positive SPT (\> 2mm) to dog and are monosensitized to the Can f 5 component, the investigatiors want to compare the reaction to conjunctival provocation (positive/negative) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures.

Time frame: 6 months

Male vs. female dog SPT in dog poly sensitized patients

In the patients that have a positive SPT (\> 2mm) to dog and are sensitized to the Can f 1, 2 and/or 3 component, the investigatiors want to compare the reaction to SPT (pos/neg) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures.

Time frame: 6 months

Male vs. female dog conjunctival provocation in dog poly sensitized patients

In the patients that have a positive SPT (\> 2mm) to dog and are sensitized to the Can f 1, 2 and/or 3 component, the investigatiors want to compare the reaction to conjunctival provocation (pos/neg) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures.

Time frame: 6 months

Can f 5 vs. SPT size

To investigate the correlation between specific Immunoglobulin E (sIgE) level to the Can f 5 component and the SPT wheal size to the male dog extract using a general linear model.

Data from ClinicalTrials.gov

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