The overall aim of this study is to investigate whether a diet rich in rye fiber from wholegrain rye, compared to refined wheat, as part of a hypocaloric diet leads to larger weight loss and lower body fat content after 12 weeks of intervention. Furthermore the study will investigate the effect on appetite as a potential underlying mechanism for differences in weight loss and body fat reduction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
242
Cereal products based on wholegrain rye
Cereal products based on refined wheat
Chalmers University of Technology
Gothenburg, Sweden
Difference in body weight
Time frame: 12 weeks
Difference in body fat mass
Time frame: 12 weeks
Appetite measured by visual analogue scale (VAS) questionnaire
Investigate if satiety differs between groups after 12 weeks of intervention and investigate if appetite correlates with changes in body weight. Measurements will be conducted through visual analogue scale (VAS) questionnaire, where participants log into a homepage and respond to their perceived satiety, hunger and desire to eat every 30-60 min during a day at base line, after 6w and 12wk.
Time frame: 12 weeks
Difference in body weight and body fat mass
Investigate if differences in body weight and body fat mass is evident already after 6 weeks
Time frame: 6 weeks
Fecal energy excretion by bomb calorimetry of 72h quantitative fecal collections.
Investigate differences in fecal energy excretion between the two intervention groups in a subgroup of 50 subjects. Every subject will be instructed to collect all feces in a special devise during 48h.
Time frame: 12 weeks
Gut microbiota
Time frame: 6 and 12 weeks
Marker of glucose metabolism
Investigate differences in hemoglobin A1c (HbA1c)
Time frame: 6 and 12 weeks
Marker of Insulin resistance
Investigate differences in homeostatic model assessment insulin resistance (HOMA-IR)
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Time frame: 6 and 12 weeks
Appetite regulation
Investigate differences in glucagon-like peptide 1(GLP-1)
Time frame: 6 and 12 weeks
Appetite
Investigate differences in leptin concentration
Time frame: 6 and 12 weeks
Marker of inflammation
Investigate differences in C-reactive protein (CRP).
Time frame: 6 and 12 weeks
Blood lipids
Investigate differences in triglyceride (TG), total cholesterol, high density lipoprotein(HDL) and low density lipoprotein (LDL).
Time frame: 6 and 12 weeks