Does Preconditioning Affects Other Organs in Patients Undergoing Open Heart Surgery ?

Assiut University100 enrolled

Overview

An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation

Preliminary evidence has suggested the role of inflammation in development and prognosis of cardiovascular diseases and cancers. Most of the prognostic studies failed to account for the effects of co-morbid conditions as these might have raised the systemic inflammation. We used neutrophil lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with cardiac preconditioning in open heart surgery .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

100

Conditions

Neutrophil Lymphocyte Ratio Serum Createnine Mechanical Ventilation

Interventions

ischemic preconditioningPROCEDURE

ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Pharmacologic preconditionigDRUG

Pharmacologic preconditionig will be attained by sevoflurane anesthesia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-60 years old * American Society of Anesthesiologists physical status II and III * Patients scheduled for open heart surgery * no active inflammatory process Exclusion Criteria:Exclusion Criteria: * Emergency surgery * Clinically significant kidney or liver disease * Patients allergic to local anesthetic * Patients with prolonged cardiopulmonary bypass time (\>120 min) * Patients required intra-aortic balloon pump * Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration

Locations (1)

Emad Zarief Kamel Said

Asyut, Egypt

Outcomes

Primary Outcomes

change of Neutrophil lymphocyte ratio

Time frame: during first two postoperative days

Data from ClinicalTrials.gov

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