Hepatitis B virus (HBV) infection remains one of the most serious health problems worldwide. Patients with chronic HBV infection are at an increased risk for developing hepatic cirrhosis, hepatocellular carcinoma and even death. Although some predictive factors of the outcome of chronic HBV infection were identified, more precisely determine the factors which are associated with the outcome in non-selected patients with chronic HBV infection are still needed. The investigators purpose is to constitute a observational cohort of non-selected Chinese patients to create a database of epidemiological, clinical, biological, virological, immunologic and therapeutic parameters, in order to determine factors associated with the outcome of chronic HBV infection.
Study Type
OBSERVATIONAL
Enrollment
20,000
The Third Hospital of Changzhou
Changzhou, Jiangsu, China
RECRUITINGHuai'an No.4 People's Hospital
Huai'an, Jiangsu, China
RECRUITINGThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China
RECRUITINGNanjing Jiangbei People's Hospital
Nanjing, Jiangsu, China
RECRUITINGSuqian People's Hospital
Suqian, Jiangsu, China
RECRUITINGThe Fifth People's Hospital of Suzhou
Suzhou, Jiangsu, China
RECRUITINGNumber of participants with antigen loss (HBeAg and HBsAg loss)
Time frame: 20 years
Cirrhosis
Time frame: 20 years
Hepatic decompensation
Development of hepatic decompensation will be defined by any of the following events: (1) Ascites or hepatic hydrothorax; (2)Variceal or portal hypertensive bleeding; (3)Hepatic encephalopathy
Time frame: 20 years
Hepatocellular carcinoma (HCC)
The diagnosis of HCC will be made using the American Association for the Study of Liver Disease criteria.
Time frame: 20 years
Death
Date and cause of death will be recorded.
Time frame: 20 years
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