Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

Virginia Commonwealth University22 enrolled

Overview

This study will assess the short term effects of a single dose of liothyronine on the cardiovascular system and energy expenditure

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

Conditions

Healthy

Interventions

LiothyronineDRUG

Single dose

LevothyroxineDRUG

Active comparator

PlacebosDRUG

Placebo

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \>20\<30 kg/m2 * TSH \>0.5\<5.0 mcIU/mL * Negative TPO antibodies Exclusion Criteria: * Pregnancy * Use of prescription drugs * Diabetes mellitus * Coronary artery disease * Hypertension * Anemia * Renal insufficiency * Liver disease or ALT \>2.5 x the upper laboratory reference limit

Locations (1)

Virginia Commonwealth University

Richmond, Virginia, United States

Outcomes

Primary Outcomes

Cardiac Output

Cardiac output measured by Echocaridogram, Difference in Stroke Volume Pre- and Post- Drug Administration

Time frame: five hours

Secondary Outcomes

Energy Expenditure

Energy expenditure measured by Whole-Room Indirect Calorimeter, Difference in energy Expenditure Pre- and Post- Drug Administration Kcal

Time frame: five hours

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.