Heart Rate Variability Under Propofol and Sevoflurane

Hôpital Armand Trousseau40 enrolled

Overview

Patients were randomized into 2 groups according to the anesthetic, propofol or sevoflurane. Induction and maintenance were standardized, and after the end of surgery, two steady-state recordings were performed at BIS 25 and BIS 55. Bispectral Index and ECG were continuously recorded and cardiac autonomic nervous activity was investigated using spectral analysis of RR Interval variability

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

General Anesthesia

Interventions

SevofluraneDRUG

General anesthesia using sevoflurane as a hypnotic agent

PropofolDRUG

General anesthesia using propofol as a hypnotic agent

RemifentanilDRUG

General anesthesia using remifentanil as an analgesic.

Eligibility

Sex: ALLMin age: 13 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA risk classification 1 or 2, * scheduled for middle ear surgery, or cardiovascular ANS activity. Exclusion Criteria: * preoperative medications that interfere with the autonomic nervous system * preoperative medications that interfere with the central nervous system

Locations (1)

Departement d'anesthesie Hopital Armand Trousseau

Paris, France

Outcomes

Primary Outcomes

Spectral analysis of heart rate variability with a bispectral index of 25

Fast Fourier Transform applied to heart rate signal recording

Time frame: During surgical procedure

Spectral analysis of heart rate variability with a bispectral index of 55

Fast Fourier Transform applied to heart rate signal recording

Time frame: During surgical procedure

Data from ClinicalTrials.gov

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