An Open-label, Non-comparative Study to Document the Tolerability to Ramipril in Patients With at Least One High Risk for Developing a Major Cardiovascular Event

Inclusion criteria : * Man or woman, age 55 years old or more. * Presence of a high risk of developing a major cardiovascular event, defined as at least one of the following underlying conditions: * Clinical evidence of coronary artery disease (examples: previous myocardial infarction \[MI\], positive stress test or significant stenosis at coronary angiography, previous Percutaneous Trans-Luminal Coronary Angioplasty \[PTCA\], previous Coronary Arterial Bypass Grafting \[CABG\]); * Clinical evidence of peripheral vascular disease (examples: history of intermittent claudication with positive Doppler or angiography, previous limb bypass surgery, previous percutaneous trans-luminal angioplasty, previous limb or foot amputation); * Previous stroke; * Diabetes (insulin-dependent or non-insulin dependent) with at least one of the following cardiovascular risk factors: * hypertension (blood pressure \[BP\] \>140/90 mmHg, or patients on antihypertensive treatment); * hypercholesterolemia (total cholesterol \> 5.2 mmol/L \[\>200 mg/dL\]); * low HDL cholesterol (\< 0.9 mmol/L \[\<3.5 mg/dL\]); * current cigarette smoking; * documented microalbuminuria (30-300 mg/24 hours); * Evidence of previous vascular disease. Exclusion criteria: * Patients with contraindications to ramipril use (as per the local Ramipril Product Information) * hypersensitivity * pregnancy, lactation * bilateral renal stenosis * Patients with clinically relevant concomitant disease that could compromise the patient's safety or follow up. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.