Ezetimibe possesses pharmacophore features to inhibit NTCP, the receptor required for HBV and HDV hepatocyte entry that include two hydrophobes and one hydrogen bond acceptor. Therapy with Ezetimibe may lead to decline in hepatitis D virus levels. The aim of the study is to evaluate the utility of Ezetimibe in patients with chronic HDV infection
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Ezetimibe 20 mg oral daily
Ziauddin University Hospital
Karachi, Sindh, Pakistan
RECRUITING• Decline of HDV RNA quantitative measurements of >1 logs from baseline
Time frame: 12 weeks of therapy
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