Cytoscopic Antibiotic Irrigant to Reduce Postoperative Urinary Tract Infection

MetroHealth Medical Center242 enrolled

Overview

Postoperative urinary tract infections (UTIs) affect 20-30% of patients undergoing elective gynecologic surgery and have a significant socioeconomic impact and cost. Preoperative antibiotics, sterile operating techniques, postoperative antibiotic and non-antibiotic medical therapies have been utilized to attempt to decrease this rate with little improvement. Utilization of an intraoperative antibiotic cystoscopic irrigant may decrease postoperative UTIs. The investigators have designed a prospective randomized controlled study to evaluate the effectiveness of an antibiotic cystoscopic fluid in preventing postoperative urinary tract infections in women undergoing elective pelvic floor surgery with cystoscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

242

Conditions

Urinary Tract Infections

Interventions

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult women at least 18 years of age * Elective Female Pelvic Medicine and Reconstructive Surgery or Gynecologic Minimally Invasive surgeries including hysterectomy, suburethral sling, and pelvic organ prolapse repair that require cystoscopy. Exclusion Criteria: * Surgeries that include: intradetrusor Botox, vaginal mesh excision, and fistula repair * Pregnancy * History of nephrolithiasis * Allergy to study medications * Congenital urogenital anomaly * Neurogenic bladder

Outcomes

Primary Outcomes

Urinary Tract Infection

Urinary tract infection defined as positive urinalysis, urine culture, and/or positive lower urinary tract symptoms requiring antibiotic treatment.

Time frame: 4 weeks